Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071706" target="_blank" >RIV/00159816:_____/19:00071706 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/19:00108545
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11910-019-1006-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs11910-019-1006-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11910-019-1006-z" target="_blank" >10.1007/s11910-019-1006-z</a>
Alternative languages
Result language
angličtina
Original language name
Gray Matter Changes in Parkinson's and Alzheimer's Disease and Relation to Cognition
Original language description
Purpose of Review We summarize structural (s)MRI findings of gray matter (GM) atrophy related to cognitive impairment in Alzheimer's disease (AD) and Parkinson's disease (PD) in light of new analytical approaches and recent longitudinal studies results. Recent Findings The hippocampus-to-cortex ratio seems to be the best sMRI biomarker to discriminate between various AD subtypes, following the spatial distribution of tau pathology, and predict rate of cognitive decline. PD is clinically far more variable than AD, with heterogeneous underlying brain pathology. Novel multivariate approaches have been used to describe patterns of early subcortical and cortical changes that relate to more malignant courses of PD. New emerging analytical approaches that combine structural MRI data with clinical and other biomarker outcomes hold promise for detecting specific GM changes in the early stages of PD and preclinical AD that may predict mild cognitive impairment and dementia conversion.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Neurology and Neuroscience Reports
ISSN
1528-4042
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
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UT code for WoS article
000497702100001
EID of the result in the Scopus database
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