Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071710" target="_blank" >RIV/00159816:_____/19:00071710 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00112623

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0022510X1930382X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0022510X1930382X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2019.116450" target="_blank" >10.1016/j.jns.2019.116450</a>

Result language

angličtina

Original language name

Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study

Original language description

Background and purpose: Autonomic nervous system (ANS) seems to play an important role in the post-stroke immunosuppression syndrome with increased susceptibility to infections. The aim of this study was to investigate if ANS activity measured at admission is associated with post-stroke infections. Methods: We prospectively analyzed patients with acute ischemic stroke. ANS was measured using the cross-correlational baroreflex sensitivity (BRS) at admission. The occurrence and cause of in-hospital infections was assessed based on the clinical and laboratory examination. Demographic and clinical variables including initial stroke severity, dysphagia, procedures as nasogastric tubes, central venous and urinary catheters and mechanical ventilation were included in the analysis. Results: We included 161 patients with ischemic stroke, of those 49 (30.4%) developed a nosocomial infection during the first 7 days of hospital stay. Patients with infections had significantly lower BRS (median 3 vs 5 ms/mmHg, p&lt;.001) higher initial NIHSS (median 15 vs 5, p&lt;.001), had more often non-lacunar etiology and underwent more invasive procedures. In the multivariable regression model decreased BRS (adjusted OR 1.21, 95% CI 1.03-1.41, p=.02), admission NIHSS (adjusted OR 1.10, 95% CI 1.02-1.19, p=.02) and invasive procedures (adjusted OR 1.46, 95% CI 1.03-2.06, p=.03) were independently associated with infection after ischemic stroke. Conclusions: Decreased BRS was independently associated with infections after ischemic stroke. Autonomic shift may play an important role in increased susceptibility to infections after stroke. The possible diagnostic and therapeutic relevance of this finding deserves further research.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

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Volume of the periodical

406

Issue of the periodical within the volume

NOV 15

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

"UNSP 116450"

UT code for WoS article

000499766400015

EID of the result in the Scopus database

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