Structural Biology and Protein Engineering of Thrombolytics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00072512" target="_blank" >RIV/00159816:_____/19:00072512 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/19:00108351
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S2001037019302065?token=20DE2F9C28C8F726B8C39CED743688E302229BF5F8AFDF1199FB4188CFEA91356AB4EF67CEC21FB0CD9677187F4F5AEF" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S2001037019302065?token=20DE2F9C28C8F726B8C39CED743688E302229BF5F8AFDF1199FB4188CFEA91356AB4EF67CEC21FB0CD9677187F4F5AEF</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.csbj.2019.06.023" target="_blank" >10.1016/j.csbj.2019.06.023</a>
Alternative languages
Result language
angličtina
Original language name
Structural Biology and Protein Engineering of Thrombolytics
Original language description
Myocardial infarction and ischemic stroke are the most frequent causes of death or disability worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used for their treatment. Improving the effectiveness of thrombolytics for clinical uses is of great interest. The knowledge of the multiple roles of the endogenous thrombolytics and the fibrinolytic system grows continuously. The effects of thrombolytics on the alteration of the nervous system and the regulation of the cell migration offer promising novel uses for treating neurodegenerative disorders or targeting cancer metastasis. However, secondary activities of thrombolytics may lead to life-threatening side-effects such as intracranial bleeding and neurotoiddty. Here we provide a structural biology perspective on various thrombolytic enzymes and their key properties: (i) effectiveness of clot lysis, (ii) affinity and specificity towards fibrin, (iii) biological half-life, (iv) mechanisms of activation/inhibition, and (v) risks of side effects. This information needs to be carefully considered while establishing protein engineering strategies aiming at the development of novel thrombolytics. Current trends and perspectives are discussed, including the screening for novel enzymes and small molecules, the enhancement of fibrin specificity by protein engineering, the suppression of interactions with native receptors, liposomal encapsulation and targeted release, the application of adjuvants, and the development of improved production systems.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Computational and Structural Biotechnology Journal
ISSN
2001-0370
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
2019
Country of publishing house
SE - SWEDEN
Number of pages
22
Pages from-to
917-938
UT code for WoS article
000504205700091
EID of the result in the Scopus database
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