Immunoexpression of Macroh2a in Uveal Melanoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00072518" target="_blank" >RIV/00159816:_____/19:00072518 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2076-3417/9/16/3244/htm" target="_blank" >https://www.mdpi.com/2076-3417/9/16/3244/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/app9163244" target="_blank" >10.3390/app9163244</a>
Alternative languages
Result language
angličtina
Original language name
Immunoexpression of Macroh2a in Uveal Melanoma
Original language description
MacroH2A is a histone variant whose expression has been studied in several neoplasms, including cutaneous melanomas (CMs). In the literature, it has been demonstrated that macroH2A.1 levels gradually decrease during CM progression, and a high expression of macroH2A.1 in CM cells relates to a better prognosis. Although both uveal and cutaneous melanomas arise from melanocytes, uveal melanoma (UM) is biologically and genetically distinct from the more common cutaneous melanoma. Metastasis to the liver is a frequent occurrence in UM, and about 40%-50% of patients die of metastatic disease, even with early diagnosis, proper treatment, and close follow-up. We wanted to investigate macroH2A.1 immunohistochemical expression in UM. Our results demonstrated that mH2A.1 expression was higher in metastatic UM (21/23, 91.4%), while only 18/32 (56.3%). UMs without metastases showed mH2A.1 staining. These data could suggest a possible prognostic role for mH2A.1 and could form a basis for developing new pharmacological strategies for UM treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/EF15_003%2F0000492" target="_blank" >EF15_003/0000492: Unveiling the molecular determinants of agingto design new therapeutics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
APPLIED SCIENCES-BASEL
ISSN
2076-3417
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
16
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
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UT code for WoS article
000484444100038
EID of the result in the Scopus database
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