Choroid plexus and the blood-cerebrospinal fluid barrier in disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073041" target="_blank" >RIV/00159816:_____/20:00073041 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00116013
Result on the web
<a href="https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-020-00196-2" target="_blank" >https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-020-00196-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12987-020-00196-2" target="_blank" >10.1186/s12987-020-00196-2</a>
Alternative languages
Result language
angličtina
Original language name
Choroid plexus and the blood-cerebrospinal fluid barrier in disease
Original language description
The choroid plexus (CP) forming the blood-cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-endothelial convolute comprising a highly vascularized stroma with fenestrated capillaries and a continuous lining of epithelial cells joined by apical tight junctions (TJs) that are crucial in forming the B-CSF barrier. Integrity of the CP is critical for maintaining brain homeostasis and B-CSF barrier permeability. Recent experimental and clinical research has uncovered the significance of the CP in the pathophysiology of various diseases affecting the CNS. The CP is involved in penetration of various pathogens into the CNS, as well as the development of neurodegenerative (e.g., Alzheimer ' s disease) and autoimmune diseases (e.g., multiple sclerosis). Moreover, the CP was shown to be important for restoring brain homeostasis following stroke and trauma. In addition, new diagnostic methods and treatment of CP papilloma and carcinoma have recently been developed. This review describes and summarizes the current state of knowledge with regard to the roles of the CP and B-CSF barrier in the pathophysiology of various types of CNS diseases and sets up the foundation for further avenues of research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/EF16_027%2F0008360" target="_blank" >EF16_027/0008360: Postdoc@MUNI</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fluids and Barriers of the CNS
ISSN
2045-8118
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
29
Pages from-to
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UT code for WoS article
000533940400002
EID of the result in the Scopus database
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