Matrix metalloproteinases gene variants and dental caries in Czech children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073055" target="_blank" >RIV/00159816:_____/20:00073055 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00116012

Result on the web

<a href="https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-020-01130-6" target="_blank" >https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-020-01130-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12903-020-01130-6" target="_blank" >10.1186/s12903-020-01130-6</a>

Result language

angličtina

Original language name

Matrix metalloproteinases gene variants and dental caries in Czech children

Original language description

Background Matrix metalloproteinases (MMPs) play an important role in tooth formation and the mineralization of dental tissue. The aim of the study was to analyse Czech children with primary/permanent dentition polymorphisms in those genes encoding MMP2, MMP3, MMP9, MMP13, MMP16, and MMP20, which had been previously associated with dental caries in other populations. Methods In total, 782 Czech children were included in this case-control study. DNA samples were taken from 474 subjects with dental caries (with decayed/missing/filled teeth, DMFT &gt;= 1) and 155 caries free children (DMFT = 0) aged 13-15 years, as well as 101 preschool children with early childhood caries (ECC, dmft &gt;= 1) and 52 caries free children (dmft = 0), were analyzed for nine MMPs single nucleotide polymorphisms (SNPs) using real time polymerase chain reaction TaqMan assays. Results There were no significant differences in the allele and/or genotype frequencies of all the studied MMPs SNPs among children with dental caries in primary/permanent dentition and the healthy controls (P &gt; 0.05). In addition, similar allele or genotype frequencies of the studied MMPs SNPs were found in children with severe dental caries in their permanent teeth (children with DMFT &gt;= 6) and the healthy controls (DMFT = 0, P &gt; 0.05). Conclusions This study demonstrated the lack of association between the selected SNPs in candidate genes of MMPs and the susceptibility to or severity of dental caries in both primary and permanent dentitions in Czech children.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Oral Health

ISSN

1472-6831

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

000535616700001

EID of the result in the Scopus database

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