Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00100931" target="_blank" >RIV/00216224:14110/18:00100931 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/18:00068707
Result on the web
<a href="http://dx.doi.org/10.1007/s00784-017-2280-2" target="_blank" >http://dx.doi.org/10.1007/s00784-017-2280-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00784-017-2280-2" target="_blank" >10.1007/s00784-017-2280-2</a>

Result language
angličtina
Original language name
Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children
Original language description
Objectives The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children. Materials and methods This study comprised 905 Czech children. Totally, 187 children aged 2-6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft >= 1)] were included in this case-control study. In addition, 177 subjects aged 13-15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT >= 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method. Results No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions. Conclusions Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30208 - Dentistry, oral surgery and medicine

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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