Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073203" target="_blank" >RIV/00159816:_____/20:00073203 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00116365 RIV/00843989:_____/20:E0108537

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1525505020303590?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1525505020303590?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yebeh.2020.107180" target="_blank" >10.1016/j.yebeh.2020.107180</a>

Result language

angličtina

Original language name

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

Original language description

Purpose: The purpose of the study was to evaluate cerebral morphological changes in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and their relationship to the cerebellum. Methods: The study cohort included 21 patients with intractable TLE-HS (14 left-sided, 7 right-sided) and 38 healthy controls (HC). All patients later underwent anteromedial temporal lobe resection. All subjects were examined using a 1.5-T magnetic resonance imaging (MRI). Volumes of distinct cerebral and cerebellar structures were measured using voxel-based morphometry. The structural covariance of temporal lobe structures, insula, and thalamus with cerebellar substructures was examined using partial least squares regression. Results: Morphological changes were more significant in the group with left TLE-HS when comparing left-sided with right-sided structures as well as when comparing patients with controls. The gray matter volume (GMV) of the temporal lobe structures was smaller ipsilaterally to the seizure onset side in most cases. There was a significant amygdala enlargement contralateral to the side of hippocampal sclerosis in both patients with right and left TLE-HS as compared with controls. Selected vermian structures in patients with left but not right TLE-HS had significantly larger GMV than the identical substructures in controls. The structural covariance differed significantly between patients with left and right TLE-HS as compared with HC. The analysis revealed significant negative covariance between anterior vermin and mesial temporal structures in the group with left TLE-HS. No significance was observed for the group with right TLE-HS. Conclusion: There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLEHS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus. (C) 2020 Elsevier Inc. All rights reserved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Epilepsy &amp; Behavior

ISSN

1525-5050

e-ISSN

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Volume of the periodical

111

Issue of the periodical within the volume

OCT 2020

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

107180

UT code for WoS article

000577327900017

EID of the result in the Scopus database

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