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Magnetic resonance spectroscopy of the thalamus in patients with mesial temporal lobe epilepsy and hippocampal sclerosis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F07%3A00000756" target="_blank" >RIV/00023001:_____/07:00000756 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/07:00028081

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Magnetic resonance spectroscopy of the thalamus in patients with mesial temporal lobe epilepsy and hippocampal sclerosis

  • Original language description

    Purpose: to investigate potential neuronal dysfunction within the thalamus in patients suffering from mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE/HS). Methods: we examined twenty epileptic patients suffering from mesial temporal lobe epilepsy with hippocampal sclerosis (17 females, 3 males) and twenty sex- and age-matched healthy controls. H MR spectroscopic imaging (SI) was performed over the right and left thalamus in all patients and controls. In addition both hippocampi were investigated by the H MR spectroscopic single voxel (SV) technique in both groups. Results: statistical analysis of compared data in both groups demonstrated that the total thalamic NAA level was significantly decreased in patients with MTLE/HS as compared tohealthy controls. Detailed analysis revealed a statistically significant reduction of NAA, NAA/Cr and NAA/(Cr+Cho) ratios in the thalamus ipsilateral to hippocampus affected with hippocampal sclerosis in patients compared to controls, wh

  • Czech name

    MR spektroskopie thalamu u pacientů s epilepsií v mesiální oblasti

  • Czech description

    Cílem studie bylo prokázat možné poškození thalamu u pacientů trpících meziální temporální epilepsií s hippokampální sklerózou. Celkem bylo vyšetřeno 20 zdravých dobrovolníků a 20 pacientů, s využitím techniky 1H MR spektroskopického zobrazování (CSI). Vipsilaterálním thalamu byla nalezena signifikantně nižší hodnota metabolitů NAA, NAA/Cr, NAA/(Cr+Cho). Výsledek studie prokazuje metabolické postižení ipsilaterálního thalamu u pacientů s meziální temporální epilepsií a hippokampální sklerózou.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LC554" target="_blank" >LC554: Neuroscience Centre</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Epileptic disorders

  • ISSN

    1294-9361

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    suppl. 1

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    9

  • Pages from-to

    59-67

  • UT code for WoS article

  • EID of the result in the Scopus database