Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00077899" target="_blank" >RIV/00209805:_____/18:00077899 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/18:00102189 RIV/00159816:_____/18:00068706
Result on the web
<a href="http://www.epilepsybehavior.com/article/S1525-5050(17)30526-7/pdf" target="_blank" >http://www.epilepsybehavior.com/article/S1525-5050(17)30526-7/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yebeh.2017.11.014" target="_blank" >10.1016/j.yebeh.2017.11.014</a>
Alternative languages
Result language
angličtina
Original language name
Predictive value of preoperative statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy with hippocampal sclerosis
Original language description
Objective: This study was designed to use statistical parametric mapping of interictal positron-emission tomography using [18F]Fluorodeoxyglucose (FDG-PET) to compare the brain metabolisms of patients with mesial temporal lobe epilepsy (MTLE)/hippocampal sclerosis and controls. Another aim of this study was to analyze the potential differences among patients in terms of epilepsy duration, side of hippocampal sclerosis, histopathological findings, insult in their history, and postoperative outcomes. Methods:Weanalyzed FDG-PET scans from49 patientswithMTLE/hippocampal sclerosis and 24 control subjects. We analyzed the differences in regional glucose metabolism between the patients and the control group and within the patient group using multiple variables. Results: We observed widespread hypometabolismin the patient group in comparisonwith the control group in temporal and extratemporal areas on the epileptogenic side (ES). On the nonepileptogenic side (NES), we observed the most hypometabolism in the thalamus and the anterior and middle cingulate gyrus. In the group of patients with more severe hippocampal sclerosis, we observed statistically significant hypometabolism in the insula on the ES. In patientswith poor postoperative outcomes, wefound statistically significant hypometabolism in the insula on the ES and the temporal pole (TP) on the NES. Patients with any insult in their history showed hypermetabolism in the TP on both sides. Conclusion: Our study showed that there are widespread changes in metabolism in patients with MTLE in comparison to controls, either inside or outside the temporal lobe. There are significant differences among these patients in terms of postoperative outcomes, degree of hippocampal sclerosis, and insults in their history.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epilepsy & behavior
ISSN
1525-5050
e-ISSN
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Volume of the periodical
79
Issue of the periodical within the volume
únor 2018
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
46-52
UT code for WoS article
000426435800009
EID of the result in the Scopus database
2-s2.0-85038034691