Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073477" target="_blank" >RIV/00159816:_____/20:00073477 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00116373

Result on the web

<a href="https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001180R" target="_blank" >https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001180R</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1096/fj.202001180R" target="_blank" >10.1096/fj.202001180R</a>

Result language

angličtina

Original language name

Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle

Original language description

Preterm infants can develop airway hyperreactivity and impaired bronchodilation following supplemental O-2(hyperoxia) in early life, making it important to understand mechanisms of hyperoxia effects. Endogenous hydrogen sulfide (H2S) has anti-inflammatory and vasodilatory effects with oxidative stress. There is little understanding of H2S signaling in developing airways. We hypothesized that the endogenous H2S system is detrimentally influenced by O(2)and conversely H2S signaling pathways can be leveraged to attenuate deleterious effects of O-2. Using human fetal airway smooth muscle (fASM) cells, we investigated baseline expression of endogenous H2S machinery, and effects of exogenous H2S donors NaHS and GYY4137 in the context of moderate hyperoxia, with intracellular calcium regulation as a readout of contractility. Biochemical pathways for endogenous H2S generation and catabolism are present in fASM, and are differentially sensitive to O(2)toward overall reduction in H2S levels. H2S donors have downstream effects of reducing [Ca2+](i)responses to bronchoconstrictor agonist via blunted plasma membrane Ca(2+)influx: effects blocked by O-2. However, such detrimental O(2)effects are targetable by exogenous H2S donors such as NaHS and GYY4137. These data provide novel information regarding the potential for H2S to act as a bronchodilator in developing airways in the context of oxygen exposure.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FASEB Journal

ISSN

0892-6638

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

12991-13004

UT code for WoS article

000558418100001

EID of the result in the Scopus database

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