Maternal Perinatal Nutrition and Offspring Programming
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073491" target="_blank" >RIV/00159816:_____/20:00073491 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/B9780128045725000161" target="_blank" >https://www.sciencedirect.com/science/article/pii/B9780128045725000161</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-804572-5.00016-1" target="_blank" >10.1016/B978-0-12-804572-5.00016-1</a>
Alternative languages
Result language
angličtina
Original language name
Maternal Perinatal Nutrition and Offspring Programming
Original language description
Maternal nutrition during pregnancy, and other perinatal periods, programs offspring physiology and metabolism, as well as the risk of suffering metabolic diseases during adulthood. During pregnancy, there is a double interaction of nutritional intake and genetic background due to the maternal feeding and genes, and fetal genetic information and in utero nutrient availability. The main molecular mechanism implicated in developmental programming appears to be epigenetics, which regulate gene expression patterns during embryo and postnatal stages in a cellular- and tissue-specific manner, affecting metabolic and physiologic-related key genes. Epigenetic profiles are nutritionally modulated, and also the expression patterns of genes related to nutrient metabolism can be epigenetic driven. Therefore, there appears a novel scientific perspective involving nutriepigenetic and nutriepigenomic regulation, which has to be integrated into the traditional nutrigenetic and nutrigenomic lines of sight. Interestingly, maternal programming may predispose the transcriptomic patterns during different lifetime periods and appear to be also transmissible across successive generations. Although human studies of developmental programming are recent and mainly observational, there is evidence of epigenetically driven programming due to different macro- and micronutrient distribution as well as by total caloric intake. However, although omics-based human approaches have importantly increased the knowledge for future nutrition-based epigenetic regulation, ethical and practical considerations lead to animal approaches as the most useful mechanistic research tool. There is still needed a deeper understanding of the nutritionally driven epigenetic reactions in utero that may lead to apply an effective personalized maternal nutrition during pregnancy.
Czech name
—
Czech description
—
Classification
Type
C - Chapter in a specialist book
CEP classification
—
OECD FORD branch
30308 - Nutrition, Dietetics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Principles of Nutrigenetics and Nutrigenomics
ISBN
978-0-12-804572-5
Number of pages of the result
7
Pages from-to
1-7
Number of pages of the book
586
Publisher name
Academic Press
Place of publication
London
UT code for WoS chapter
—