Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073515" target="_blank" >RIV/00159816:_____/20:00073515 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/21/20/7549" target="_blank" >https://www.mdpi.com/1422-0067/21/20/7549</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms21207549" target="_blank" >10.3390/ijms21207549</a>

Result language
angličtina
Original language name
Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
Original language description
Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds' potential to be utilized as quality chemical biology probes.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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