Response to Vagal Stimulation by Heart-rate Features in Drug-resistant Epileptic Patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00074072" target="_blank" >RIV/00159816:_____/20:00074072 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1109/EMBC44109.2020.9176326" target="_blank" >http://dx.doi.org/10.1109/EMBC44109.2020.9176326</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/EMBC44109.2020.9176326" target="_blank" >10.1109/EMBC44109.2020.9176326</a>

Result language
angličtina
Original language name
Response to Vagal Stimulation by Heart-rate Features in Drug-resistant Epileptic Patients
Original language description
Vagal Nerve Stimulation (VNS) is an option in the treatment of drug-resistant epilepsy. However, approximately a quarter of VNS subjects does not respond to the therapy. In this retrospective study, we introduce heart-rate features to distinguish VNS responders and non-responders. Standard pre-implantation measurements of 66 patients were segmented in relation to specific stimuli (open/close eyes, photic stimulation, hyperventilation, and rests between). Median interbeat intervals were found for each segment and normalized (NMRR). Five NMRRs were significant; the strongest feature achieved significance with p=0.013 and AUC=0.66. Low mutual correlation and independence on EEG signals mean that presented features could be considered as an addition for models predicting VNS response using EEG.
Czech name
—
Czech description
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Project
<a href="/en/project/NV19-04-00343" target="_blank" >NV19-04-00343: Prediction of Stimulation Efficacy in Epilepsy (PRESEnCE)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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