PHAGOCYTOSIS-INFLAMMATION CROSSTALK IN SEPSIS: NEW AVENUES FOR THERAPEUTIC INTERVENTION
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00074099" target="_blank" >RIV/00159816:_____/20:00074099 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00118327 RIV/00023736:_____/20:00013135
Result on the web
<a href="https://journals.lww.com/shockjournal/Fulltext/2020/11000/Phagocytosis_Inflammation_Crosstalk_in_Sepsis__New.4.aspx" target="_blank" >https://journals.lww.com/shockjournal/Fulltext/2020/11000/Phagocytosis_Inflammation_Crosstalk_in_Sepsis__New.4.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/SHK.0000000000001541" target="_blank" >10.1097/SHK.0000000000001541</a>
Alternative languages
Result language
angličtina
Original language name
PHAGOCYTOSIS-INFLAMMATION CROSSTALK IN SEPSIS: NEW AVENUES FOR THERAPEUTIC INTERVENTION
Original language description
Phagocytosis is a complex process by which cells within most organ systems remove pathogens and cell debris. Phagocytosis is usually followed by inflammatory pathway activation, which promotes pathogen elimination and inhibits pathogen growth. Delayed pathogen elimination is the first step in sepsis development and a key factor in sepsis resolution. Phagocytosis thus has an important role during sepsis and likely contributes to all of its clinical stages. However, only a few studies have specifically explored and characterized phagocytic activity during sepsis. Here, we describe the phagocytic processes that occur as part of the immune response preceding sepsis onset and identify the elements of phagocytosis that might constitute a predictive marker of sepsis outcomes. First, we detail the key features of phagocytosis, including the main receptors and signaling hallmarks associated with different phagocytic processes. We then discuss how the initial events of phagosome formation and cytoskeletal remodeling might be associated with known sepsis features, such as a cytokine-driven hyperinflammatory response and immunosuppression. Finally, we highlight the unresolved mechanisms of sepsis development and progression and the need for cross-disciplinary approaches to link the clinical complexity of the disease with basic cellular and molecular mechanisms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30221 - Critical care medicine and Emergency medicine
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Shock
ISSN
1073-2322
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
606-614
UT code for WoS article
000619501000004
EID of the result in the Scopus database
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