Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00073479" target="_blank" >RIV/00159816:_____/21:00073479 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00120673

Result on the web

<a href="https://www.liebertpub.com/doi/10.1089/ars.2019.7983" target="_blank" >https://www.liebertpub.com/doi/10.1089/ars.2019.7983</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/ars.2019.7983" target="_blank" >10.1089/ars.2019.7983</a>

Result language

angličtina

Original language name

Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation

Original language description

Significance:Since their discovery, induced pluripotent stem cells (iPSCs) had generated considerable interest in the scientific community for their great potential in regenerative medicine, disease modeling, and cell-based therapeutic approach, due to their unique characteristics of self-renewal and pluripotency. Recent Advances:Technological advances in iPSC genome-wide epigenetic profiling led to the elucidation of the epigenetic control of cellular identity during nuclear reprogramming. Moreover, iPSC physiology and metabolism are tightly regulated by oxidation-reduction events that mainly occur during the respiratory chain. In theory, iPSC-derived differentiated cells would be ideal for stem cell transplantation as autologous cells from donors, as the risks of rejection are minimal. Critical Issues:However, iPSCs experience high oxidative stress that, in turn, confers a high risk of increased genomic instability, which is most often linked to DNA repair deficiencies. Genomic instability has to be assessed before iPSCs can be used in therapeutic designs. Future Directions:This review will particularly focus on the links between redox balance and epigenetic modifications-in particular based on the histone variant macroH2A1-that determine DNA damage response in iPSCs and derived differentiated cells, and that might be exploited to decrease the teratogenic potential on iPSC transplantation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/EF15_003%2F0000492" target="_blank" >EF15_003/0000492: Unveiling the molecular determinants of agingto design new therapeutics</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ANTIOXIDANTS &amp; REDOX SIGNALING

ISSN

1523-0864

e-ISSN

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Volume of the periodical

34

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

335-349

UT code for WoS article

000555879000001

EID of the result in the Scopus database

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