Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075188" target="_blank" >RIV/00159816:_____/21:00075188 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/21:00075188 RIV/00216224:14110/21:00120148
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2213158221002746?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2213158221002746?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nicl.2021.102830" target="_blank" >10.1016/j.nicl.2021.102830</a>
Alternative languages
Result language
angličtina
Original language name
Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies
Original language description
Longitudinal comorbidity of depression and cognitive impairment has been reported by number of epidemiological studies but the underlying mechanisms explaining the link between affective problems and cognitive decline are not very well understood. Imaging studies have typically investigated patients with major depressive disorder (MDD) and mild cognitive impairment (MCI) separately and thus have not identified a structural brain signature common to these conditions that may illuminate potentially targetable shared biological mechanisms. We performed a meta-analysis of. 48 voxel-based morphometry (VBM) studies of individuals with MDD, MCI, and age-matched controls and demonstrated that MDD and MCI patients had shared volumetric reductions in a number of regions including the insula, superior temporal gyrus (STG), inferior frontal gyrus, amygdala, hippocampus, and thalamus. We suggest that the shared volumetric reductions in the insula and STG might reflect communication deficits and infrequent participation in mentally or socially stimulating activities, which have been described as risk factors for both MCI and MDD. We also suggest that the disease-specific structural changes might reflect the disease-specific symptoms such as poor integration of emotional information, feelings of helplessness and worthlessness, and anhedonia in MDD. These findings could contribute to better understanding of the origins of MDD-MCI comorbidity and facilitate development of early interventions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NeuroImage-Clinical
ISSN
2213-1582
e-ISSN
—
Volume of the periodical
32
Issue of the periodical within the volume
2021
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
102830
UT code for WoS article
000702826200006
EID of the result in the Scopus database
2-s2.0-85115371617