Development and Testing of Thrombolytics in Stroke

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075257" target="_blank" >RIV/00159816:_____/21:00075257 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/21:00121798

Result on the web

<a href="https://www.j-stroke.org/journal/view.php?doi=10.5853/jos.2020.03349" target="_blank" >https://www.j-stroke.org/journal/view.php?doi=10.5853/jos.2020.03349</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5853/jos.2020.03349" target="_blank" >10.5853/jos.2020.03349</a>

Result language

angličtina

Original language name

Development and Testing of Thrombolytics in Stroke

Original language description

Despite recent advances in recanalization therapy, mechanical thrombectomy will never be a treatment for every ischemic stroke because access to mechanical thrombectomy is still limited in many countries. Moreover, many ischemic strokes are caused by occlusion of cerebral arteries that cannot be reached by intra-arterial catheters. Reperfusion using thrombolytic agents will therefore remain an important therapy for hyperacute ischemic stroke. However, thrombolytic drugs have shown limited efficacy and notable hemorrhagic complication rates, leaving room for improvement. A comprehensive understanding of basic and clinical research pipelines as well as the current status of thrombolytic therapy will help facilitate the development of new thrombolytics. Compared with alteplase, an ideal thrombolytic agent is expected to provide faster reperfusion in more patients; prevent re-occlusions; have higher fibrin specificity for selective activation of clot-bound plasminogen to decrease bleeding complications; be retained in the blood for a longer time to minimize dosage and allow administration as a single bolus; be more resistant to inhibitors; and be less antigenic for repetitive usage. Here, we review the currently available thrombolytics, strategies for the development of new clot-dissolving substances, and the assessment of thrombolytic efficacies in vitro and in vivo.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Stroke

ISSN

2287-6391

e-ISSN

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Volume of the periodical

23

Issue of the periodical within the volume

1

Country of publishing house

KR - KOREA, REPUBLIC OF

Number of pages

25

Pages from-to

12-36

UT code for WoS article

000672470600002

EID of the result in the Scopus database

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