Reperfusion therapies of acute ischemic stroke: potentials and failures

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061273" target="_blank" >RIV/00159816:_____/14:00061273 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3389/fneur.2014.00215" target="_blank" >http://dx.doi.org/10.3389/fneur.2014.00215</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fneur.2014.00215" target="_blank" >10.3389/fneur.2014.00215</a>

Result language

angličtina

Original language name

Reperfusion therapies of acute ischemic stroke: potentials and failures

Original language description

Over the past 20 years, clinical research has focused on the development of reperfusion therapies for acute ischemic stroke (AIS), which include the use of systemic intravenous thrombolytics (alteplase, desmoteplase, or tenecteplase), the augmentation ofsystemic intravenous recanalization with ultrasound, the bridging of intravenous with intra-arterial thrombolysis, the use of multi-modal approaches to reperfusion including thrombectomy and thromboaspiration with different available retrievers. Clinical trials testing these acute reperfusion therapies provided novel insight regarding the comparative safety and efficacy, but also raised new questions and further uncertainty on the field. Intravenous alteplase (tPA) remains the fastest and easiestway toinitiate acute stroke reperfusion treatment, and should continue to be the first-line treatment for patients with AIS within 4.5 h from onset. The use of tenecteplase instead of tPA and the augmentation of systemic thrombolysis with ultr

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Neurology

ISSN

1664-2295

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

OCT

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

215

UT code for WoS article

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EID of the result in the Scopus database

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