The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076208" target="_blank" >RIV/00159816:_____/22:00076208 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/22:00126060
Result on the web
<a href="https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-022-00312-4" target="_blank" >https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-022-00312-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12987-022-00312-4" target="_blank" >10.1186/s12987-022-00312-4</a>
Alternative languages
Result language
angličtina
Original language name
The blood-brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments
Original language description
The response of the blood-brain barrier (BBB) following a stroke, including subarachnoid hemorrhage (SAH), has been studied extensively. The main components of this reaction are endothelial cells, pericytes, and astrocytes that affect microglia, neurons, and vascular smooth muscle cells. SAH induces alterations in individual BBB cells, leading to brain homeostasis disruption. Recent experiments have uncovered many pathophysiological cascades affecting the BBB following SAH. Targeting some of these pathways is important for restoring brain function following SAH. BBB injury occurs immediately after SAH and has long-lasting consequences, but most changes in the pathophysiological cascades occur in the first few days following SAH. These changes determine the development of early brain injury as well as delayed cerebral ischemia. SAH-induced neuroprotection also plays an important role and weakens the negative impact of SAH. Supporting some of these beneficial cascades while attenuating the major pathophysiological pathways might be decisive in inhibiting the negative impact of bleeding in the subarachnoid space. In this review, we attempt a comprehensive overview of the current knowledge on the molecular and cellular changes in the BBB following SAH and their possible modulation by various drugs and substances.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF16_027%2F0008360" target="_blank" >EF16_027/0008360: Postdoc@MUNI</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fluids and Barriers of the CNS
ISSN
2045-8118
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
79
Pages from-to
nestrankovano
UT code for WoS article
000780995700001
EID of the result in the Scopus database
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