Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076266" target="_blank" >RIV/00159816:_____/22:00076266 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/22:00127441

Result on the web

<a href="https://link.springer.com/article/10.1007/s00702-022-02519-z" target="_blank" >https://link.springer.com/article/10.1007/s00702-022-02519-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-022-02519-z" target="_blank" >10.1007/s00702-022-02519-z</a>

Result language

angličtina

Original language name

Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae

Original language description

White Matter Lesions (WML) are a radiological finding common in aged subjects. We explored the impact of WML on underlying neurodegenerative processes. We focused on the impact of WML on two neurodegenerative diseases with different pathology. In this cross-sectional study of 137 subjects (78 female, 59 men, mean age 67.2; 43-87 years), we compared WML in healthy controls (HC; n = 55), patients with Alzheimer&apos;s disease and amnestic Mild Cognitive Impairment (aMCI), and Parkinson&apos;s disease patients with normal cognition and with MCI. Subjects with AD and aMCI were treated as one group (n = 40), subjects with PD and PDMCI were another group (n = 42). MRI T2_FLAIR sequences were analyzed. WML were divided into periventricular (pWML) or subcortical (sWML) depending on their distance from the ventricles. Subjects from the AD + aMCI group, had a significantly greater volume of WML than both HC and the PD + PDMCI group. The volume of WML was greater in the PD + PDMCI than in HC but the difference was not significant. In AD + aMCI subjects, sWML and not pWML were related to a decrease in global cognitive functioning despite greater volume of pWML. In PD + PDMCI, pWML correlate with decline in executive functions and working memory. In HC, pWML correlated with the multidomain decrease corresponding with the aging. This points to a difference between normal aging and pathological aging due to AD and PD brain pathology. The WML location together with underlying disease related neurodegeneration may play a role in determining the effect of WML on cognition. Our results suggest that the impact of WML is not uniform in all patients; rather, their volume, location and cognitive effect may be disease-specific.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

1435-1463

Volume of the periodical

129

Issue of the periodical within the volume

8

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

1023-1030

UT code for WoS article

000823317800001

EID of the result in the Scopus database

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