The reduction of hippocampal volume in Parkinson's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076599" target="_blank" >RIV/00159816:_____/22:00076599 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/22:00126466
Result on the web
<a href="https://link.springer.com/article/10.1007/s00702-021-02451-8" target="_blank" >https://link.springer.com/article/10.1007/s00702-021-02451-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00702-021-02451-8" target="_blank" >10.1007/s00702-021-02451-8</a>
Alternative languages
Result language
angličtina
Original language name
The reduction of hippocampal volume in Parkinson's disease
Original language description
The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson's disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neural Transmission
ISSN
0300-9564
e-ISSN
1435-1463
Volume of the periodical
129
Issue of the periodical within the volume
5-6
Country of publishing house
AT - AUSTRIA
Number of pages
6
Pages from-to
575-580
UT code for WoS article
000751224300001
EID of the result in the Scopus database
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