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The reduction of hippocampal volume in Parkinson's disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076599" target="_blank" >RIV/00159816:_____/22:00076599 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14740/22:00126466

  • Result on the web

    <a href="https://link.springer.com/article/10.1007/s00702-021-02451-8" target="_blank" >https://link.springer.com/article/10.1007/s00702-021-02451-8</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00702-021-02451-8" target="_blank" >10.1007/s00702-021-02451-8</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The reduction of hippocampal volume in Parkinson's disease

  • Original language description

    The volume of the hippocampus decreases more slowly than the volume of the cortex during normal aging. We explored changes in the hippocampus-to-cortex volume (HV:CTV) ratio with increasing age in non-demented Parkinson&apos;s disease (PD) patients as compared to healthy controls (HC). We also evaluated the association between the HV:CTV ratio and cognitive outcomes. Altogether 130 participants without dementia aged 51-88 years were consecutively enrolled, including 54 PD patients (mean age 67, standard deviation (SD) 8 years) and 76 HC (mean age 69, SD 7 years). All participants underwent structural magnetic resonance examination and psychological evaluation. Hippocampal and cortex volumes were determined from T1 and FLAIR scans using FreeSurfer software, and the HV:CTV ratio was calculated. Regression lines for age-dependence of the HV:CTV ratio for PD and HC groups were calculated. We further assessed the association between the HV:CTV ratio and cognitive tests examining hippocampus-related cognitive functions. PD patients and age-matched HC showed a significant difference in age-dependence of HV:CTV ratio (p value = 0.012), with a decreasing slope in PD and increasing slope in HC. In the PD group, a significant correlation (R = 0.561, p = 0.024) was observed between the HV:CTV ratio and the Digit Symbol-Coding test. The reduction of HV:CTV ratio is accelerated in pathological aging due to PD pathology. The HV:CTV ratio was associated with impaired processing speed, i.e., the cognitive function that is linked to subcortical alterations of both associated basal ganglia circuitry and the hippocampus.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30210 - Clinical neurology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Neural Transmission

  • ISSN

    0300-9564

  • e-ISSN

    1435-1463

  • Volume of the periodical

    129

  • Issue of the periodical within the volume

    5-6

  • Country of publishing house

    AT - AUSTRIA

  • Number of pages

    6

  • Pages from-to

    575-580

  • UT code for WoS article

    000751224300001

  • EID of the result in the Scopus database