The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076292" target="_blank" >RIV/00159816:_____/22:00076292 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/22:00076292 RIV/00209805:_____/22:00079075 RIV/00216224:14740/22:00129731

Result on the web

<a href="https://www.mdpi.com/2072-6694/14/14/3386" target="_blank" >https://www.mdpi.com/2072-6694/14/14/3386</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers14143386" target="_blank" >10.3390/cancers14143386</a>

Result language

angličtina

Original language name

The Significance of MicroRNAs in the Molecular Pathology of Brain Metastases

Original language description

Simple Summary Brain metastases are increasingly common in cancer patients and hurt survival and quality of life. Therefore, efforts are increasingly devoted to research into brain metastases and discovering new diagnostic approaches and therapeutic targets. MicroRNAs, which are involved in regulating most cellular processes, including metastasis, appear to be promising molecules in this regard. The number of studies on microRNAs is constantly increasing. This review aims to summarize the current knowledge on the importance of microRNAs in the pathobiology of brain metastases and to suggest possibilities for their use in diagnostic and therapeutic practice. Brain metastases are the most frequent intracranial tumors in adults and the cause of death in almost one-fourth of cases. The incidence of brain metastases is steadily increasing. The main reason for this increase could be the introduction of new and more efficient therapeutic strategies that lead to longer survival but, at the same time, cause a higher risk of brain parenchyma infiltration. In addition, the advances in imaging methodology, which provide earlier identification of brain metastases, may also be a reason for the higher recorded number of patients with these tumors. Metastasis is a complex biological process that is still largely unexplored, influenced by many factors and involving many molecules. A deeper understanding of the process will allow the discovery of more effective diagnostic and therapeutic approaches that could improve the quality and length of patient survival. Recent studies have shown that microRNAs (miRNAs) are essential molecules that are involved in specific steps of the metastatic cascade. MiRNAs are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression and thus regulate most cellular processes. The dysregulation of these molecules has been implicated in many cancers, including brain metastases. Therefore, miRNAs represent promising diagnostic molecules and therapeutic targets in brain metastases. This review summarizes the current knowledge on the importance of miRNAs in brain metastasis, focusing on their involvement in the metastatic cascade and their potential clinical implications.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NV18-03-00398" target="_blank" >NV18-03-00398: Extension of established prognostic scores in brain metastases by microRNA profiling to tailor the post-operative personalized care</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers

ISSN

2072-6694

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

14

Country of publishing house

CH - SWITZERLAND

Number of pages

23

Pages from-to

3386

UT code for WoS article

000832241700001

EID of the result in the Scopus database

2-s2.0-85136353724