Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076331" target="_blank" >RIV/00159816:_____/22:00076331 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/22:10443165 RIV/00216208:11110/22:10443165 RIV/00216224:14110/22:00125641

Result on the web

<a href="https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3" target="_blank" >https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-022-02115-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12903-022-02115-3" target="_blank" >10.1186/s12903-022-02115-3</a>

Result language

angličtina

Original language name

Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case-control study

Original language description

Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied ACE I/D polymorphisms were not significantly different between subjects with/without RAS (P-corr &gt; 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21-1.12, P = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09-1.17, P &lt; 0.035, P-corr &gt; 0.05, respectively) than in men with RAS (P &gt; 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70-110.79, P = 0.0012, P-corr &lt; 0.05). In subanalysis, TGD haplotype was significantly more frequent in RAS patients (P &lt; 0.00001) and CGI haplotype was less frequent in RAS patients (P &lt; 0.01), especially in women (P = 0.016, P-corr &gt; 0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Oral Health

ISSN

1472-6831

e-ISSN

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Volume of the periodical

22

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

80

UT code for WoS article

000770760100002

EID of the result in the Scopus database

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