Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10411400" target="_blank" >RIV/00216208:11110/20:10411400 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/20:00115430 RIV/00159816:_____/20:00072880 RIV/00064165:_____/20:10411400

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dVJq.zC-D7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dVJq.zC-D7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jop.12993" target="_blank" >10.1111/jop.12993</a>

Result language

angličtina

Original language name

Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis

Original language description

Background: The development of recurrent aphthous stomatitis (RAS), inflammatory disease of oral mucosa, is influenced by both environmental and genetic factors. The aim of this study was to investigate polymorphisms located in seven genes coding different types of matrix metalloproteinases (MMPs)-collagenases (MMP1, MMP8, and MMP13), gelatinases (MMP2 and MMP9), stromelysin (MMP3), and membrane-type metalloproteinase (MMP16) in patients with RAS and healthy controls. Methods: Totally, 223 subjects were included in this case-control study and their detailed anamnestic, clinical, and laboratory parameters were recorded. Seventy-seven patients with RAS and 146 controls were genotyped for seventeen polymorphisms in the MMPs genes using the real-time polymerase chain reaction (PCR) or PCR with restriction analysis. Results: Allele, genotype, and haplotype frequencies of the studied polymorphisms between RAS patients and controls were similar, except for allele distributions of MMP1 rs1144393, MMP9 rs3918242, and MMP16 rs10429371, which were different between patients with RAS and healthy controls (P = .023, P = .049 and P = .025, all P corr &gt; 0.05, respectively). Moreover, the comparison of genotype frequencies (TT vs CC + CT) of the MMP16 rs10429371 variant showed a marginally significant difference between RAS patients and controls (P = .05, P corr &gt; 0.05, OR = 1.68, 95% CI = 0.95-2.98). Conclusions: No significant relationship between investigated polymorphisms in seven MMPs genes and RAS development in the Czech population was observed in this study.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Oral Pathology and Medicine

ISSN

0904-2512

e-ISSN

—

Volume of the periodical

49

Issue of the periodical within the volume

3

Country of publishing house

DK - DENMARK

Number of pages

7

Pages from-to

271-277

UT code for WoS article

000511596800001

EID of the result in the Scopus database

2-s2.0-85079161381