Characteristics of subjective cognitive decline associated with amyloid positivity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077556" target="_blank" >RIV/00159816:_____/22:00077556 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/22:10434935 RIV/00216208:11130/22:10434935
Result on the web
<a href="https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12512" target="_blank" >https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12512</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/alz.12512" target="_blank" >10.1002/alz.12512</a>

Result language
angličtina
Original language name
Characteristics of subjective cognitive decline associated with amyloid positivity
Original language description
Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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