Lactate from the tumor microenvironment - A key obstacle in NK cell-based immunotherapies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077726" target="_blank" >RIV/00159816:_____/22:00077726 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/22:00013470 RIV/00216208:11310/22:10454839

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2022.932055/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2022.932055/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2022.932055" target="_blank" >10.3389/fimmu.2022.932055</a>

Result language

angličtina

Original language name

Lactate from the tumor microenvironment - A key obstacle in NK cell-based immunotherapies

Original language description

Recent findings about the new roles of lactate have changed our understanding of this end product of glycolysis or fermentation that was once considered only a waste product. It is now well accepted that lactate acts as a signaling molecule and fuel source for cancer cells in a glucose-restricted environment. Moreover, lactate and lactate dehydrogenase are markers of poor prognosis of many cancers and regulate many functions of immune cells. The presence of lactate in the tumor microenvironment (TME) leads to polarization of the immunosuppressive phenotypes of dendritic cells and impairs the cytotoxic abilities of T cells and NK cells, and as such lactate is a major obstacle to immune-cell effector functions and the efficacy of cell-based immunotherapies. Emerging evidence suggests that lactate in the TME might be a novel therapeutic target to enhance the immunotherapeutic potential of cell-based therapies. This review describes our current understanding of the role of lactate in tumor biology, including its detrimental effects on cell-based immunotherapy in cancer. We also highlight how the role of lactate in the TME must be considered when producing cell therapies designed for adoptive transfer and describe how targeted modulation of lactate in the TME might boost immune-cell functions and positively impact cellular immunotherapy, with a focus on NK cell.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

October

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

nestrankovano

UT code for WoS article

000878517400001

EID of the result in the Scopus database

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