The effect of aspartate β-hydroxylase inhibition on cancer immunotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10485836" target="_blank" >RIV/00216208:11310/24:10485836 - isvavai.cz</a>
Result on the web
<a href="https://www.pivac-prague.cz/" target="_blank" >https://www.pivac-prague.cz/</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
The effect of aspartate β-hydroxylase inhibition on cancer immunotherapy
Original language description
Aspartate β-hydroxylase (ASPH) is overexpressed in 70-90% of various solid tumors, contributing to tumor cell proliferation, migration, and invasion. In addition, recombinant ASPH inhibits natural killer (NK) cells, but an effect on other immune cells has not been described. Small molecule inhibitors have been developed to target tumors overexpressing ASPH. In this study, we combined ASPH inhibition with immunotherapy to enhance cancer therapy and seek out affected immune cells.
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů