Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077947" target="_blank" >RIV/00159816:_____/22:00077947 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41591-022-02041-5" target="_blank" >https://www.nature.com/articles/s41591-022-02041-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41591-022-02041-5" target="_blank" >10.1038/s41591-022-02041-5</a>

Result language

angličtina

Original language name

Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved

Original language description

The EMPEROR-Preserved trial showed that the sodium-glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF) &gt; 40%. Here, we report the results of a pre-specified analysis that separately evaluates these patients stratified by LVEF: preserved (GREATER-THAN OR EQUAL TO 50%) (n = 4,005; 66.9%) or mid-range (41-49%). In patients with LVEF GREATER-THAN OR EQUAL TO 50%, empagliflozin reduced the risk of cardiovascular death or HHF (the primary endpoint) by 17% versus placebo (hazard ratio (HR) 0.83; 95% confidence interval (CI): 0.71-0.98, P = 0.024). For the key secondary endpoint, the HR for total HHF was 0.83 (95%CI: 0.66-1.04, P = 0.11). For patients with an LVEF of 41-49%, the HR for empagliflozin versus placebo was 0.71 (95%CI: 0.57-0.88, P = 0.002) for the primary outcome (Pinteraction = 0.27), and 0.57 (95%CI: 0.42-0.79, P &lt; 0.001) for total HHF (Pinteraction = 0.06). These results, together with those from the EMPEROR-Reduced trial in patients with LVEF &lt; 40%, support the use of empagliflozin across the full spectrum of LVEF in heart failure. (C) 2022, The Author(s).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30200 - Clinical medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature medicine

ISSN

1078-8956

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

2512-2520

UT code for WoS article

000896466000001

EID of the result in the Scopus database

2-s2.0-85143362333