Empagliflozin benefits in patients with heart failure and preserved ejection fraction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F22%3A00128843" target="_blank" >RIV/00216224:14110/22:00128843 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41591-022-02041-5" target="_blank" >https://www.nature.com/articles/s41591-022-02041-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41591-022-02041-5" target="_blank" >10.1038/s41591-022-02041-5</a>

Result language

angličtina

Original language name

Empagliflozin benefits in patients with heart failure and preserved ejection fraction

Original language description

The EMPEROR-Preserved trial showed that the sodium–glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF)  &gt; 40%. Here, we report the results of a pre-specified analysis that separately evaluates these patients stratified by LVEF: preserved (≥ 50%) (n = 4,005; 66.9%) or mid-range (41–49%). In patients with LVEF  ≥ 50%, empagliflozin reduced the risk of cardiovascular death or HHF (the primary endpoint) by 17% versus placebo (hazard ratio (HR) 0.83; 95% confidence interval (CI): 0.71–0.98, P = 0.024). For the key secondary endpoint, the HR for total HHF was 0.83 (95%CI: 0.66–1.04, P = 0.11). For patients with an LVEF of 41–49%, the HR for empagliflozin versus placebo was 0.71 (95%CI: 0.57–0.88, P = 0.002) for the primary outcome (Pinteraction = 0.27), and 0.57 (95%CI: 0.42–0.79, P &lt; 0.001) for total HHF (Pinteraction = 0.06). These results, together with those from the EMPEROR-Reduced trial in patients with LVEF &lt; 40%, support the use of empagliflozin across the full spectrum of LVEF in heart failure.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NATURE MEDICINE

ISSN

1078-8956

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

12

Country of publishing house

DE - GERMANY

Number of pages

18

Pages from-to

„2512“-„+“

UT code for WoS article

000896466000001

EID of the result in the Scopus database

2-s2.0-85143362333