Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00076316" target="_blank" >RIV/00159816:_____/23:00076316 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00134622

Result on the web

<a href="https://journals.sagepub.com/doi/10.1177/17085381221102812" target="_blank" >https://journals.sagepub.com/doi/10.1177/17085381221102812</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/17085381221102812" target="_blank" >10.1177/17085381221102812</a>

Result language

angličtina

Original language name

Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection

Original language description

Objective The purpose of our study was to describe perioperative kinetics of procalcitonin (PCT) in patients undergoing aortic surgery, to compare the kinetics in the open abdominal aortic aneurysm (AAA) repair and aortobifemoral bypass for aortoiliac occlusive disease (AIOD), and to evaluate the ability of PCT to detect intestinal ischaemia. Methods A prospective non-randomized observational cohort study in 80 patients (62 men and 18 women) undergoing elective aortic surgery was performed. Serum PCT was measured at baseline and defined intraoperative and postoperative timepoints up to postoperative day 7. MRI contrast-enhanced imaging was used to detect intestinal ischaemia. Results The comparison of the AAA and AIOD cohort did not show any significant difference in PCT levels. Patients with intestinal ischaemia had higher serum PCT at multiple timepoints postoperatively. The most accurate timepoints for early diagnosis were postoperative day 3, followed by 24 h after declamping of the vascular reconstruction, and postoperative day 7. The sensitivity and negative predictive values were 100% in all mentioned timepoints. However, event at the best timepoint the specificity was 89% and the positive predictive value 43%. Conclusions Procalcitonin levels in the postoperative period at proper timepoints might help to detect postoperative intestinal ischaemia. The limitation of this marker is its low specificity for intestinal ischaemia and low positive predictive value. The highest value of this marker is that it can rule out this complication because normal PCT levels mean that intestinal ischaemia is very unlikely.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV17-29701A" target="_blank" >NV17-29701A: Ischemia modified albumin and circulating microRNAs as a new technology for monitoring of tissue ischemia following abdominal aortic vascular surgery</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vascular

ISSN

1708-5381

e-ISSN

1708-539X

Volume of the periodical

31

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

1061-1068

UT code for WoS article

000805273500001

EID of the result in the Scopus database

2-s2.0-85130912830