Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00078707" target="_blank" >RIV/00159816:_____/23:00078707 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00134627

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0009912022002715?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0009912022002715?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2022.12.002" target="_blank" >10.1016/j.clinbiochem.2022.12.002</a>

Result language

angličtina

Original language name

Kinetics of D-lactate and ischemia-modified albumin after abdominal aortic surgery and their ability to predict intestinal ischemia

Original language description

Objectives: Acute intestinal ischemia is a severe complication of abdominal aortic surgery that is difficult to diagnose early and therefore to treat adequately and timely. In this study the perioperative kinetics of D-lactate and ischemia-modified albumin (IMA) are described and the predictive value of these markers for the early diagnosis of acute intestinal ischemia is assessed.Design &amp; methods: This non-randomised, single-centre cohort study enrolled 50 patients with abdominal aortic aneurysm (AAA) and 30 patients with aortoiliac occlusive disease (AOID). Serum D-lactate and IMA were assessed pre-, intra-, and postoperatively at eight defined time points.Results: The highest serum D-lactate was at 6 h after complete declamping of the vascular graft. The highest predictive power of D-lactate was at 3 h after complete declamping (AUC 0.857). IMA was found to be higher in the AAA group in ischemic patients 10 min after complete declamping than in the AOID group. The highest predictive values of IMA were at 1 h after aortic cross-clamping (AUC 0.758) and 3 and 6 h after complete declamping (0.745 and 0.721, respectively). Moreover, the multivariate model with both markers at 3 h after complete declamping improved the detection of intestinal ischemia (AUC 0.894).Conclusions: Serum levels of IMA and D-lactate seem to be influential predictive markers for postoperative intestinal ischemia, especially after 3 h from complete declamping of vascular reconstruction.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30200 - Clinical medicine

Project

<a href="/en/project/NV17-29701A" target="_blank" >NV17-29701A: Ischemia modified albumin and circulating microRNAs as a new technology for monitoring of tissue ischemia following abdominal aortic vascular surgery</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

1873-2933

Volume of the periodical

112

Issue of the periodical within the volume

FEB 2023

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

43-47

UT code for WoS article

000923758200001

EID of the result in the Scopus database

2-s2.0-85144808793