Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case-control study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00076729" target="_blank" >RIV/00159816:_____/23:00076729 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130142 RIV/65269705:_____/23:00076729

Result on the web

<a href="https://link.springer.com/content/pdf/10.1007/s00784-022-04794-2.pdf?pdf=button" target="_blank" >https://link.springer.com/content/pdf/10.1007/s00784-022-04794-2.pdf?pdf=button</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00784-022-04794-2" target="_blank" >10.1007/s00784-022-04794-2</a>

Result language

angličtina

Original language name

Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case-control study

Original language description

Objectives Dental caries is a widespread multifactorial disease, caused by the demineralization of hard dental tissues. Susceptibility to dental caries is partially genetically conditioned; this study was aimed at finding an association of selected single nucleotide polymorphisms (SNPs) in genes encoding proteins involved in amelogenesis with this disease in children. Materials and methods In this case-control study, 15 SNPs in ALOX15, AMBN, AMELX, KLK4, TFIP11, and TUFT1 genes were analyzed in 150 children with primary dentition and 611 children with permanent teeth with/without dental caries from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) cohort. Results Dental caries in primary dentition was associated with SNPs in AMELX (rs17878486) and KLK4 (rs198968, rs2242670), and dental caries in permanent dentition with SNPs in AMELX (rs17878486) and KLK4 (rs2235091, rs2242670, rs2978642), (p &lt;= 0.05). No significant differences between cases and controls were observed in the allele or genotype frequencies of any of the selected SNPs in ALOX15, AMBN, TFIP11, and TUFT1 genes (p &gt; 0.05). Some KLK4 haplotypes were associated with dental caries in permanent dentition (p &lt;= 0.05). Conclusions Based on this study, we found that although the SNPs in AMELX and KLK4 are localized in intronic regions and their functional significance has not yet been determined, they are associated with susceptibility to dental caries in children.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30208 - Dentistry, oral surgery and medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Oral Investigations

ISSN

1432-6981

e-ISSN

1436-3771

Volume of the periodical

27

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

15

Pages from-to

1681-1695

UT code for WoS article

000887864400001

EID of the result in the Scopus database

2-s2.0-85142529264