The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00078694" target="_blank" >RIV/00159816:_____/23:00078694 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/23:00132933

Result on the web

<a href="https://www.nature.com/articles/s41531-023-00508-x" target="_blank" >https://www.nature.com/articles/s41531-023-00508-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41531-023-00508-x" target="_blank" >10.1038/s41531-023-00508-x</a>

Result language

angličtina

Original language name

The effect of deep brain stimulation in Parkinson's disease reflected in EEG microstates

Original language description

Mechanisms of deep brain stimulation (DBS) on cortical networks were explored mainly by fMRI. Advanced analysis of high-density EEG is a source of additional information and may provide clinically useful biomarkers. The presented study evaluates EEG microstates in Parkinson&apos;s disease and the effect of DBS of the subthalamic nucleus (STN). The association between revealed spatiotemporal dynamics of brain networks and changes in oscillatory activity and clinical examination were assessed. Thirty-seven patients with Parkinson&apos;s disease treated by STN-DBS underwent two sessions (OFF and ON stimulation conditions) of resting-state EEG. EEG microstates were analyzed in patient recordings and in a matched healthy control dataset. Microstate parameters were then compared across groups and were correlated with clinical and neuropsychological scores. Of the five revealed microstates, two differed between Parkinson&apos;s disease patients and healthy controls. Another microstate differed between ON and OFF stimulation conditions in the patient group and restored parameters in the ON stimulation state toward to healthy values. The mean beta power of that microstate was the highest in patients during the OFF stimulation condition and the lowest in healthy controls; sources were localized mainly in the supplementary motor area. Changes in microstate parameters correlated with UPDRS and neuropsychological scores. Disease specific alterations in the spatiotemporal dynamics of large-scale brain networks can be described by EEG microstates. The approach can reveal changes reflecting the effect of DBS on PD motor symptoms as well as changes probably related to non-motor symptoms not influenced by DBS.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

npj Parkinsons Disease

ISSN

2373-8057

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

63

UT code for WoS article

000989780900001

EID of the result in the Scopus database

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