Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F21%3A00549312" target="_blank" >RIV/68081731:_____/21:00549312 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/21:00119591 RIV/00159816:_____/21:00074854
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/hbm.25642" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/hbm.25642</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/hbm.25642" target="_blank" >10.1002/hbm.25642</a>
Alternative languages
Result language
angličtina
Original language name
Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease
Original language description
The degree of response to subthalamic nucleus deep brain stimulation (STN-DBS) is individual and hardly predictable. We hypothesized that DBS-related changes in cortical network organization are related to the clinical effect. Network analysis based on graph theory was used to evaluate the high-density electroencephalography (HDEEG) recorded during a visual three-stimuli paradigm in 32 Parkinson's disease (PD) patients treated by STN-DBS in stimulation off and on states. Preprocessed scalp data were reconstructed into the source space and correlated to the behavioral parameters. In the majority of patients (n = 26), STN-DBS did not lead to changes in global network organization in large-scale brain networks. In a subgroup of suboptimal responders (n = 6), identified according to reaction times (RT) and clinical parameters (lower Unified Parkinson's Disease Rating Scale [UPDRS] score improvement after DBS and worse performance in memory tests), decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas were detected. The important role of the supplementary motor area for the optimal DBS response was demonstrated by the increased node strength and eigenvector centrality in good responders. This response was missing in the suboptimal responders. Cortical topologic architecture is modified by the response to STN-DBS leading to a dysfunction of the large-scale networks in suboptimal responders.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Human Brain Mapping
ISSN
1065-9471
e-ISSN
1097-0193
Volume of the periodical
42
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
5626-5635
UT code for WoS article
000689718000001
EID of the result in the Scopus database
2-s2.0-85113563918