Intraoperative electrophysiological monitoring determines the final electrode position for pallidal stimulation in dystonia patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00078795" target="_blank" >RIV/00159816:_____/23:00078795 - isvavai.cz</a>

Alternative codes found

RIV/00843989:_____/23:E0110300 RIV/00216224:14110/23:00134639

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fsurg.2023.1206721/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fsurg.2023.1206721/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fsurg.2023.1206721" target="_blank" >10.3389/fsurg.2023.1206721</a>

Result language

angličtina

Original language name

Intraoperative electrophysiological monitoring determines the final electrode position for pallidal stimulation in dystonia patients

Original language description

BackgroundBilateral deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective treatment for refractory dystonia. Neuroradiological target and stimulation electrode trajectory planning with intraoperative microelectrode recordings (MER) and stimulation are used. With improving neuroradiological techniques, the need for MER is in dispute mainly because of the suspected risk of hemorrhage and the impact on clinical post DBS outcome.ObjectiveThe aim of the study is to compare the preplanned GPi electrode trajectories with final trajectories selected for electrode implantation after electrophysiological monitoring and to discuss the factors potentially responsible for differences between preplanned and final trajectories. Finally, the potential association between the final trajectory selected for electrode implantation and clinical outcome will be analyzed.MethodsForty patients underwent bilateral GPi DBS (right-sided implants first) for refractory dystonia. The relationship between preplanned and final trajectories (MicroDrive system) was correlated with patient (gender, age, dystonia type and duration) and surgery characteristics (anesthesia type, postoperative pneumocephalus) and clinical outcome measured using CGI (Clinical Global Impression parameter). The correlation between the preplanned and final trajectories together with CGI was compared between patients 1-20 and 21-40 for the learning curve effect.ResultsThe trajectory selected for definitive electrode implantation matched the preplanned trajectory in 72.5% and 70% on the right and left side respectively; 55% had bilateral definitive electrodes implanted along the preplanned trajectories. Statistical analysis did not confirm any of the studied factors as predictor of the difference between the preplanned and final trajectories. Also no association between CGI and final trajectory selected for electrode implantation in the right/left hemisphere has been proven. The percentages of final electrodes implanted along the preplanned trajectory (the correlation between anatomical planning and intraoperative electrophysiology results) did not differ between patients 1-20 and 21-40. Similarly, there were no statistically significant differences in CGI (clinical outcome) between patients 1-20 and 21-40.ConclusionThe final trajectory selected after electrophysiological study differed from the preplanned trajectory in a significant percentage of patients. No predictor of this difference was identified. The anatomo-electrophysiological difference was not predictive of the clinical outcome (as measured using CGI parameter).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30200 - Clinical medicine

Project

<a href="/en/project/NV19-04-00343" target="_blank" >NV19-04-00343: Prediction of Stimulation Efficacy in Epilepsy (PRESEnCE)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FRONTIERS IN SURGERY

ISSN

2296-875X

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

MAY 22

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

1206721

UT code for WoS article

000998908800001

EID of the result in the Scopus database

2-s2.0-85161048991