Microelectrode Neuronal Activity of the Internal Globus Pallidus in Dystonia Correlates with Postoperative Neuromodulation Effects and Placement of the Stimulation Electrode

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00334850" target="_blank" >RIV/68407700:21460/19:00334850 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10396386

Result on the web

<a href="https://doi.org/10.1016/j.irbm.2019.05.006" target="_blank" >https://doi.org/10.1016/j.irbm.2019.05.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.irbm.2019.05.006" target="_blank" >10.1016/j.irbm.2019.05.006</a>

Result language

angličtina

Original language name

Microelectrode Neuronal Activity of the Internal Globus Pallidus in Dystonia Correlates with Postoperative Neuromodulation Effects and Placement of the Stimulation Electrode

Original language description

Deep brain stimulation (DBS) is emerging as a viable treatment option for selected patients with dystonia. Intraoperative extracellular microelectrode recordings (MER) are considered as the standard electrophysiological method for the precise positioning of the DBS electrode into the target brain structure. Accurate targeting of the permanent stimulation electrode into the Globus Pallidus internus (GPi) is key to positive long-term effects. The suitability of the location is peroperatively assessed by microelectrodes that register single-unit neuronal activity. The aim of this article is to analyse electrophysiological recordings of patient's neuronal activity with a focus on the identification of markers relevant to the patient's clinical state. In this study, 13 patients chronically treated with double-sided DBS GPi were examined with a microrecording. The signal (24 kHz) processing, included bandpass filtering (0.5–5 kHz), automated detection of artefacts and feature extraction. Pre-processed signals were analysed by means of statistical learning. The results show that the GPi was distinguished from its vicinity with p < 0.001 and 3 machine learning models AUCs had an accuracy of higher than 0.87. The observed biomarker, Hjort mobility, additionally correlated with the long-term neuromodulation effect (rho = -0.4; p < 0.05). Furthermore, we revealed a change of neural activity associated with the active distal DBS contact localization along the medio-lateral direction. This paper demonstrates the quantitative relationship between electrophysiological findings and the clinical effects of pallidal stimulation in dystonia and suggested objectification predictors of the effectiveness of this therapy.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20601 - Medical engineering

Project

<a href="/en/project/NV16-28119A" target="_blank" >NV16-28119A: Analysis of movement disorders for the study of extrapyramidal diseases mechanisms using motion capture camera systems</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Innovation and Research in BioMedical engineering

ISSN

1959-0318

e-ISSN

1876-0988

Volume of the periodical

40

Issue of the periodical within the volume

4

Country of publishing house

FR - FRANCE

Number of pages

8

Pages from-to

193-200

UT code for WoS article

000481562600001

EID of the result in the Scopus database

2-s2.0-85066424017