Analysis of Neural Activity of the Human Basal Ganglia in Dystonia: a Review

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00326028" target="_blank" >RIV/68407700:21460/18:00326028 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Analysis of Neural Activity of the Human Basal Ganglia in Dystonia: a Review
Original language description
Dystonia is a painful, disabling disease whose cause in many cases remains unknown. Deep brain stimulation (DBS) is emerging as a viable treatment option for selected patients with dystonia. Intraoperative extracellular microelectrode recordings (MER) are considered as the standard electrophysiological method for the precise positioning of the DBS electrode into the target brain structure. The aim of this article is to provide an overview the state-of-the-art approaches for processing of microelectrode recordings in dystonia in order to define biomarkers to identify patients who will have clinical benefit. For this purpose, the comprehensive elements of microelectrode recording and processing are examined. Next, we investigate the primary and recent studies and objectives in this field. Herein, we describe baseline elements of MER processing including data collection, preprocessing phase, features computation, spike detection and sorting and advanced spike train data analysis. This study will help readers acquire the necessary information about these elements and their associated techniques. Thus, this study is supposed to assist during identification and proposal of interesting clinical hypotheses in the field of single unit neuronal recordings in dystonia.
Czech name
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Czech description
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Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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