An analysis of neural activity of the human basal ganglia in dystonia: A review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00340927" target="_blank" >RIV/68407700:21460/19:00340927 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.14311/CTJ.2019.2.05" target="_blank" >https://doi.org/10.14311/CTJ.2019.2.05</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14311/CTJ.2019.2.05" target="_blank" >10.14311/CTJ.2019.2.05</a>

Result language

angličtina

Original language name

An analysis of neural activity of the human basal ganglia in dystonia: A review

Original language description

Deep brain stimulation of the globus pallidus internus is an efective symptomatic treatment for pharmacoresistant dystonic syndromes, where pathophysiological mechanisms of action are not yet fully understood. The aim of this review article is to provide an overview of the state-of-the-art approaches for processing of microelectrode recordings in dystonia; in order to define biomarkers to identify patients who will benefit from the clinical deep brain stimulation. For this purpose, the essential elements of microelectrode processing are examined. Next, we investigate a real example of spike sorting processing in this field. Herein, we describe baseline elements of microrecordings processing including data collection, preprocessing phase, features computation, spike detection and sorting and finally, advanced spike train data analysis. This study will help readers acquire the necessary information about these elements and their associated techniques. Thus, this study is supposed to assist during identification and proposal of interesting clinical hypotheses in the field of single unit neuronal recordings in dystonia.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

20601 - Medical engineering

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lékař a technika

ISSN

0301-5491

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

66-71

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85078675440