Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079641" target="_blank" >RIV/00159816:_____/23:00079641 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00133476

Result on the web

<a href="https://link.springer.com/article/10.1007/s11010-023-04706-2" target="_blank" >https://link.springer.com/article/10.1007/s11010-023-04706-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11010-023-04706-2" target="_blank" >10.1007/s11010-023-04706-2</a>

Result language

angličtina

Original language name

Cisplatin treatment reduces contraction to angiotensin II by altering expression of angiotensin II receptors: a pilot study

Original language description

The renin angiotensin system is a key regulator of blood pressure homeostasis. Angiotensin type 1 (AT(1)R) and 2 receptors (AT(2)R) have been investigated as targets for cisplatin-induced acute kidney injury; however, their therapeutic potential remains inconclusive. This pilot study aimed to determined the effect that acute cisplatin treatment had on angiotensin II (AngII)-induced contraction in blood vessels and expression profiles of AT(1)R and AT(2)R in mouse arteries and kidneys. Male C57BL/6 mice at 18 week of age (n=8) were treated with vehicle or bolus dose of cisplatin (12.5 mg/kg). Thoracic aorta (TA), adnominal aorta (AA), brachiocephalic arteries (BC), iliac arteries (IL) and kidneys were collected for isometric tension and immunohistochemistry analysis. Cisplatin treatment reduced IL contraction to AngII at all doses (p&lt;0.01, p&lt;0.001, p&lt;0.0001); however, AngII did not induce contraction in TA, AA or BC in either treatment group. Following cisplatin treatment, AT(1)R expression was significantly upregulated in the media of TA (p&lt;0.0001) and AA (p&lt;0.0001), and in the endothelium (p&lt;0.05) media (p&lt;0.0001) and adventitia (p&lt;0.01) of IL. Cisplatin treatment significantly reduced AT(2)R expression in the endothelium (p&lt;0.05) and media (p&lt;0.05) of TA. In renal tubules, both AT(1)R (p&lt;0.01) and AT(2)R (p&lt;0.05) were increased following cisplatin treatment. Herein, we report that cisplatin reduces AngII-mediated contraction in IL and may be explained by an absence of normal counterregulatory expression of AT(1)R and AT(2)R, indicating other factors are involved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular and Cellular Biochemistry

ISSN

0300-8177

e-ISSN

1573-4919

Volume of the periodical

478

Issue of the periodical within the volume

12

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

2907-2916

UT code for WoS article

001099394000023

EID of the result in the Scopus database

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