Angiotensin II constricts mouse iliac arteries: possible mechanism for aortic aneurysms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00079762" target="_blank" >RIV/00159816:_____/24:00079762 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135112
Result on the web
<a href="https://link.springer.com/article/10.1007/s11010-023-04724-0" target="_blank" >https://link.springer.com/article/10.1007/s11010-023-04724-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11010-023-04724-0" target="_blank" >10.1007/s11010-023-04724-0</a>
Alternative languages
Result language
angličtina
Original language name
Angiotensin II constricts mouse iliac arteries: possible mechanism for aortic aneurysms
Original language description
Abdominal aortic aneurysms (AAA) result from maladaptive remodeling of the vascular wall and reduces structural integrity. Angiotensin II (AngII) infusion has become a standard laboratory model for studying AAA initiation and progression. We determined the different vasoactive responses of various mouse arteries to Ang II. Ex vivo isometric tension analysis was conducted on 18-week-old male C57BL/6 mice (n = 4) brachiocephalic arteries (BC), iliac arteries (IL), and abdominal (AA) and thoracic aorta (TA). Arterial rings were mounted between organ hooks, gently stretched and an AngII dose response was performed. Rings were placed in 4% paraformaldehyde for immunohistochemistry analysis to quantify peptide expression of angiotensin type 1 (AT(1)R) and 2 receptors (AT(2)R) in the endothelium, media, and adventitia. Results from this study demonstrated vasoconstriction responses in IL were significantly higher at all AngII doses when compared to BC, and TA and AA responses (maximum constriction-IL: 68.64 +/- 5.47% vs. BC: 1.96 +/- 1.00%; TA: 3.13 +/- 0.16% and AA: 2.75 +/- 1.77%, p < 0.0001). Expression of AT(1)R was highest in the endothelium of IL (p < 0.05) and in the media and (p < 0.05) adventitia (p < 0.05) of AA. In contrast, AT(2)R expression was highest in endothelium (p < 0.05), media (p < 0.01, p < 0.05) and adventitia of TA. These results suggest that mouse arteries display different vasoactive responses to AngII, and the exaggerated response in IL arteries may play a role during AAA development.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Biochemistry
ISSN
0300-8177
e-ISSN
1573-4919
Volume of the periodical
479
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
233-242
UT code for WoS article
000964127200002
EID of the result in the Scopus database
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