Time-related factors predicting a positive response to cardiac resynchronisation therapy in patients with heart failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079654" target="_blank" >RIV/00159816:_____/23:00079654 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41598-023-35174-9" target="_blank" >https://www.nature.com/articles/s41598-023-35174-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-023-35174-9" target="_blank" >10.1038/s41598-023-35174-9</a>

Result language

angličtina

Original language name

Time-related factors predicting a positive response to cardiac resynchronisation therapy in patients with heart failure

Original language description

This study aimed to identify time parameters predicting favourable CRT response. A total of 38 patients with ischemic cardiomyopathy, qualified for CRT implantation, were enrolled in the study. A 15% reduction in indexed end-systolic volume after 6 months was a criterion for a positive response to CRT. We evaluated QRS duration, measured from a standard ECG before and after CRT implantation and obtained from mapping with NOGA XP system (AEMM); and the delay, measured with the implanted device algorithm (DCD) and its change after 6 months (Delta DCD); and selected delay parameters between the left and right ventricles based on AEMM data. A total of 24 patients presented with a positive response to CRT versus 9 non-responders. After CRT implantation, we observed differences between responders and non-responders group in the reduction of QRS duration (31 ms vs. 16 ms), duration of paced QRS (123 ms vs. 142 ms), and the change of Delta DCDMaximum (4.9 ms vs. 0.44 ms) and Delta DCDMean (7.7 ms vs. 0.9 ms). The difference in selected parameters obtained during AEMM in both groups was related to interventricular delay (40.3 ms vs. 18.6 ms). Concerning local activation time and left ventricular activation time, we analysed the delays in individual left ventricular segments. Predominant activation delay of the posterior wall middle segment was associated with a better response to CRT. Some AEMM parameters, paced QRS time of less than 120 ms and reduction of QRS duration greater than 20 ms predict the response to CRT. Delta DCD is associated with favourable electrical and structural remodelling.: SUM No. KNW/0022/KB1/17/15.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

8524

UT code for WoS article

001001070500061

EID of the result in the Scopus database

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