Plastic response of macrophages to metal ions and nanoparticles in time mimicking metal implant body environment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00079137" target="_blank" >RIV/00159816:_____/24:00079137 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135299 RIV/65269705:_____/24:00079137
Result on the web
<a href="https://link.springer.com/article/10.1007/s11356-023-31430-7" target="_blank" >https://link.springer.com/article/10.1007/s11356-023-31430-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11356-023-31430-7" target="_blank" >10.1007/s11356-023-31430-7</a>
Alternative languages
Result language
angličtina
Original language name
Plastic response of macrophages to metal ions and nanoparticles in time mimicking metal implant body environment
Original language description
The paradigm of using metal biomaterials could be viewed from two sides - treatment of wide spectrum of degenerative diseases, and debris release from materials. After implant insertion, metal nanoparticles (NPs) and ions are released not only upon the first contact with cells/tissues, but in continual manner, which is immediately recognized by immune cells. In this work, the effects of metal nanoparticles (TiO2, Ni) and ions (Ni2+, Co2+, Cr3+, Mo6+) on primary human M0 macrophages from the blood samples of osteoarthritic patients undergoing total arthroplasty were studied in order to monitor immunomodulatory effects on the cells in a real-time format. The highest NiNPs concentration of 10 mu g/ml had no effect on any of macrophage parameters, while the Ni2+ ions cytotoxicity limit for the cells is 0.5 mM. The cytotoxic effects of higher Ni2+ concentration revealed mitochondrial network fragmentation leading to mitochondrial dysfunction, accompanied by increased lysosomal activity and changes in pro-apoptotic markers. The suppression of M2 cell formation ability was connected to presence of Ni2+ ions (0.5 mM) and TiO2NPs (10 mu g/ml). The immunomodulatory effect of Mo6+ ions, controversially, inhibit the formation of the cells with M1 phenotype and potentiate the thread-like shape M2s with increased chaotic cell movement. To summarize, metal toxicity depends on the debris form. Both, metal ions and nanoparticles affect macrophage size, morphological and functional parameters, but the effect of ions is more complex and likely more harmful, which has potential impact on healing and determines post-implantation reactions.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
<a href="/en/project/NU20-08-00149" target="_blank" >NU20-08-00149: Multicentric evaluation of hypersensitivity reactions in patients indicated for total joint replacement including evaluation of the reasons for reimplanting</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science and Pollution Research
ISSN
0944-1344
e-ISSN
1614-7499
Volume of the periodical
31
Issue of the periodical within the volume
3
Country of publishing house
DE - GERMANY
Number of pages
19
Pages from-to
4111-4129
UT code for WoS article
001125959900001
EID of the result in the Scopus database
2-s2.0-85182954892