Phenotype and oxidative burst of low-density neutrophil subpopulations are altered in common variable immunodeficiency patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00079678" target="_blank" >RIV/00159816:_____/24:00079678 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135334
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/cyto.b.22150" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/cyto.b.22150</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cyto.b.22150" target="_blank" >10.1002/cyto.b.22150</a>
Alternative languages
Result language
angličtina
Original language name
Phenotype and oxidative burst of low-density neutrophil subpopulations are altered in common variable immunodeficiency patients
Original language description
Common variable immunodeficiency disorder (CVID) is the most common form of primary antibody immunodeficiency. Due to low antibody levels, CVID patients receive intravenous or subcutaneous immunoglobulin replacement therapy as treatment. CVID is associated with the chronic activation of granulocytes, including an increased percentage of low-density neutrophils (LDNs). In this study, we examined changes in the percentage of LDNs and the expression of their surface markers in 25 patients with CVID and 27 healthy donors (HD) after in vitro stimulation of whole blood using IVIg. An oxidative burst assay was used to assess the functionality of LDNs. CVID patients had increased both relative and absolute LDN counts with a higher proportion of mLDNs compared to iLDNs, distinguished based on the expression of CD10 and CD16. Immature LDNs in the CVID and HD groups had significantly reduced oxidative burst capacity compared to mature LDNs. Interestingly we observed reduced oxidative burst capacity, reduced expression of CD10 after stimulation of WB, and higher expression of PD-L1 in mature LDNs in CVID patients compared to HD cells. Our data indicate that that the functional characteristics of LDNs are closely linked to their developmental stage. The observed reduction in oxidative burst capacity in mLDNs in CVID patients could contribute to an increased susceptibility to recurrent bacterial infections among CVID patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cytometry Part B-Clinical Cytometry
ISSN
1552-4949
e-ISSN
1552-4957
Volume of the periodical
106
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
99-112
UT code for WoS article
001109148500001
EID of the result in the Scopus database
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