Vitamin D in blood serum and chronic pancreatitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00080282" target="_blank" >RIV/00159816:_____/24:00080282 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00137796 RIV/61988987:17110/24:A2503A45 RIV/65269705:_____/24:00080282 RIV/00843989:_____/24:E0111115

Result on the web

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DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2024_79" target="_blank" >10.4149/BLL_2024_79</a>

Result language

angličtina

Original language name

Vitamin D in blood serum and chronic pancreatitis

Original language description

Patients with chronic pancreatitis are at risk of developing malabsorption and malnutrition. Exocrine pancreatic insufficiency is accompanied by decreased serum micronutrient levels and low vitamin D levels are a frequent finding in up to 60-80% of patients. The aim of our prospective study was to investigate vitamin D in the blood serum of subjects with chronic pancreatitis with the possibility of influencing the reduced vitamin D levels with supplementation therapy. MATERIAL AND METHODOLOGY: Fifty patients with chronic pancreatitis and 20 subjects in the control group without gastrointestinal tract diseases, including pancreatic disease, were examined. The vitamin D level in blood serum was determined. The results were evaluated according to the age distribution of subjects with pancreatic disease and according to gender. Patients with low vitamin D levels were treated for 24 weeks with a dose of 1.500.000 IU of vitamin D3 per day, and then blood serum vitamin D levels were determined. RESULTS: In people with chronic pancreatitis, vitamin D levels were statistically significantly reduced compared to the control group. There was no statistically significant relationship of vitamin D with gender and age. Supplementation with vitamin D3 achieved an adjustment of vitamin D level to the level of the control group. CONCLUSION: Blood serum vitamin D levels are significantly reduced in people with chronic pancreatitis. Its correction by oral vitamin D supplementation was effective. Whether this adjustment of levels will be effective also in terms of e.g. beneficial effect on fibrogenesis will require further representative studies, because the limitation of the interpretation of the results of our study is the smaller number of subjects with chronicpancreatitis (Tab. 4, Ref. 29).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30218 - General and internal medicine

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislava Medical Journal-Bratislavske Lekarske Listy

ISSN

0006-9248

e-ISSN

1336-0345

Volume of the periodical

125

Issue of the periodical within the volume

8

Country of publishing house

SK - SLOVAKIA

Number of pages

5

Pages from-to

508-512

UT code for WoS article

001301125300009

EID of the result in the Scopus database

2-s2.0-85200168923