Hippocampal subfield volumetric changes after radiotherapy for brain metastases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00081082" target="_blank" >RIV/00159816:_____/24:00081082 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135961 RIV/00209805:_____/24:00079765 RIV/00216305:26220/24:PU155998
Result on the web
<a href="https://academic.oup.com/noa/article/6/1/vdae040/7632607" target="_blank" >https://academic.oup.com/noa/article/6/1/vdae040/7632607</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/noajnl/vdae040" target="_blank" >10.1093/noajnl/vdae040</a>
Alternative languages
Result language
angličtina
Original language name
Hippocampal subfield volumetric changes after radiotherapy for brain metastases
Original language description
Background Changes in the hippocampus after brain metastases radiotherapy can significantly impact neurocognitive functions. Numerous studies document hippocampal atrophy correlating with the radiation dose. This study aims to elucidate volumetric changes in patients undergoing whole-brain radiotherapy (WBRT) or targeted stereotactic radiotherapy (SRT) and to explore volumetric changes in the individual subregions of the hippocampus.Method Ten patients indicated to WBRT and 18 to SRT underwent brain magnetic resonance before radiotherapy and after 4 months. A structural T1-weighted sequence was used for volumetric analysis, and the software FreeSurfer was employed as the tool for the volumetry evaluation of 19 individual hippocampal subregions.Results The volume of the whole hippocampus, segmented by the software, was larger than the volume outlined by the radiation oncologist. No significant differences in volume changes were observed in the right hippocampus. In the left hippocampus, the only subregion with a smaller volume after WBRT was the granular cells and molecular layers of the dentate gyrus (GC-ML-DG) region (median change -5 mm3, median volume 137 vs. 135 mm3; P = .027), the region of the presumed location of neuronal progenitors.Conclusions Our study enriches the theory that the loss of neural stem cells is involved in cognitive decline after radiotherapy, contributes to the understanding of cognitive impairment, and advocates for the need for SRT whenever possible to preserve cognitive functions in patients undergoing brain radiotherapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
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Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuro-Oncology Advances
ISSN
2632-2498
e-ISSN
2632-2498
Volume of the periodical
6
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
"vdae040"
UT code for WoS article
001205314400001
EID of the result in the Scopus database
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