Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00081419" target="_blank" >RIV/00159816:_____/24:00081419 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/24:00135784

Result on the web

<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10967083/" target="_blank" >https://pmc.ncbi.nlm.nih.gov/articles/PMC10967083/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s11658-024-00554-0" target="_blank" >10.1186/s11658-024-00554-0</a>

Result language

angličtina

Original language name

Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease

Original language description

Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent membrane structures. It is widely recognized as an antigenic marker of stem cells and cancer stem cells and is frequently used to isolate them from biological and clinical samples. Recent progress in understanding various aspects of CD133 biology in different cell types has revealed the involvement of CD133 in the architecture and dynamics of plasma membrane protrusions, such as microvilli and cilia, including the release of extracellular vesicles, as well as in various signaling pathways, which may be regulated in part by posttranslational modifications of CD133 and its interactions with a variety of proteins and lipids. Hence, CD133 appears to be a master regulator of cell signaling as its engagement in PI3K/Akt, Src-FAK, Wnt/beta-catenin, TGF-beta/Smad and MAPK/ERK pathways may explain its broad action in many cellular processes, including cell proliferation, differentiation, and migration or intercellular communication. Here, we summarize early studies on CD133, as they are essential to grasp its novel features, and describe recent evidence demonstrating that this unique molecule is involved in membrane dynamics and molecular signaling that affects various facets of tissue homeostasis and cancer development. We hope this review will provide an informative resource for future efforts to elucidate the details of CD133&apos;s molecular function in health and disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CELLULAR &amp; MOLECULAR BIOLOGY LETTERS

ISSN

1425-8153

e-ISSN

1689-1392

Volume of the periodical

29

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

47

Pages from-to

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UT code for WoS article

001191297500001

EID of the result in the Scopus database

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