Atypical nuclear localization of CD133 plasma membrane glycoprotein in rhabdomyosarcoma cell lines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00087462" target="_blank" >RIV/00216224:14310/15:00087462 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/15:00063433 RIV/00209805:_____/15:N0000003
Result on the web
<a href="http://www.spandidos-publications.com/ijmm/36/1/65" target="_blank" >http://www.spandidos-publications.com/ijmm/36/1/65</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ijmm.2015.2210" target="_blank" >10.3892/ijmm.2015.2210</a>
Alternative languages
Result language
angličtina
Original language name
Atypical nuclear localization of CD133 plasma membrane glycoprotein in rhabdomyosarcoma cell lines
Original language description
CD133 (also known as prominin-1) is a cell surface glycoprotein that is widely used for the identification of stem cells. Furthermore, its glycosylated epitope, AC133, has recently been discussed as a marker of cancer stem cells in various human malignancies. During our recent experiments on rhabdomyosarcomas (RMS), we unexpectedly identified an atypical nuclear localization of CD133 in a relatively stable subset of cells in five RMS cell lines established in our laboratory. To the best of our knowledge, this atypical localization of CD133 has not yet been proven or analyzed in detail in cancer cells. In the present study, we verified the nuclear localization of CD133 in RMS cells using three independent anti-CD133 antibodies, including both rabbit polyclonal and mouse monoclonal antibodies.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13443" target="_blank" >NT13443: Identification and characterization of cancer stem cells in pediatric sarcomas.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Medicine
ISSN
1107-3756
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
1
Country of publishing house
GR - GREECE
Number of pages
8
Pages from-to
65-72
UT code for WoS article
000358134900007
EID of the result in the Scopus database
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