The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F11%3A00369486" target="_blank" >RIV/86652036:_____/11:00369486 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1089/ars.2010.3785" target="_blank" >http://dx.doi.org/10.1089/ars.2010.3785</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/ars.2010.3785" target="_blank" >10.1089/ars.2010.3785</a>
Alternative languages
Result language
angličtina
Original language name
The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?
Original language description
Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Antioxidants & Redox Signaling
ISSN
1523-0864
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
2989-3002
UT code for WoS article
000296588900006
EID of the result in the Scopus database
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