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The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F11%3A00369486" target="_blank" >RIV/86652036:_____/11:00369486 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1089/ars.2010.3785" target="_blank" >http://dx.doi.org/10.1089/ars.2010.3785</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1089/ars.2010.3785" target="_blank" >10.1089/ars.2010.3785</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?

  • Original language description

    Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Antioxidants & Redox Signaling

  • ISSN

    1523-0864

  • e-ISSN

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    13

  • Pages from-to

    2989-3002

  • UT code for WoS article

    000296588900006

  • EID of the result in the Scopus database