Neuroblastoma stem cells - mechanisms of chemoresistance and histonedeacetylase inhibitors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10126299" target="_blank" >RIV/00216208:11310/12:10126299 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8252 RIV/00064203:_____/12:8252

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2012_093" target="_blank" >http://dx.doi.org/10.4149/neo_2012_093</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2012_093" target="_blank" >10.4149/neo_2012_093</a>

Result language

angličtina

Original language name

Neuroblastoma stem cells - mechanisms of chemoresistance and histonedeacetylase inhibitors

Original language description

Cancer stem cells (CSCs) form a small proportion of tumor cells that have stem cell properties: self-renewal capacity, the ability to develop into different lineages and proliferative potential. The interest in CSCs emerged from their expected role in initiation, progression and recurrence of many tumors. They are generally resistant to conventional chemotherapy and radiotherapy. There are two hypotheses about their origin: The first assumes that CSCs may arise from normal stem cells, and the second supposes that differentiated cells acquire the properties of CSCs. Both hypotheses are not mutually exclusive, as it is possible that CSCs have a diverse origin in different tumors. CD133+ cells (CD133 is marker of CSC in some tumors) isolated from NBL, osteosarcoma and Ewing sarcoma cell lines are resistant to cisplatin, carboplatin, etoposide and doxorubicin than the CD133- ones. Being resistant to chemotherapy, there were many attempts to target CSCs epigenetically including the use of h

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GAP301%2F10%2F0356" target="_blank" >GAP301/10/0356: Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

6

Country of publishing house

SK - SLOVAKIA

Number of pages

10

Pages from-to

737-746

UT code for WoS article

000310820200018

EID of the result in the Scopus database

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